Reproductive, hormonal factors tied to knee OA in women

Reproductive, hormonal factors tied to knee OA in women
Female reproductive and hormonal factors are associated with incidence of knee osteoarthritis (OA), according to a study published in the July issue of Arthritis & Rheumatology.

Female reproductive and hormonal factors are associated with incidence of knee osteoarthritis (OA), according to a study published in the July issue of Arthritis & Rheumatology.

The researchers identified 1,208 TKAs for OA over 12.7 years. There was an increased risk of TKA among those ever having being pregnant (hazard ratio [HR], 1.32; 95 percent confidence interval [CI], 1.06 to 1.63). Parity also was associated with an increased risk of TKA. Oral contraceptive (OC) users had an increased risk of TKA versus non-users (OC use of less than five years: HR, 1.25 [95 percent CI, 1.08 to 1.45]; OC use of five or more years: HR, 1.17 [95 percent CI, 1.0 to 1.37]). There was a decrease in TKA risk for each one-year increase in menstruation (HR, 0.99; 95 percent CI, 0.97 to 0.99). However, with adjustments, these associations remained significant only for women of normal weight at early reproductive age.

Source: Medical Xpress

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