Female reproductive and hormonal factors are associated with incidence of knee osteoarthritis (OA), according to a study published in the July issue of Arthritis & Rheumatology.
The researchers identified 1,208 TKAs for OA over 12.7 years. There was an increased risk of TKA among those ever having being pregnant (hazard ratio [HR], 1.32; 95 percent confidence interval [CI], 1.06 to 1.63). Parity also was associated with an increased risk of TKA. Oral contraceptive (OC) users had an increased risk of TKA versus non-users (OC use of less than five years: HR, 1.25 [95 percent CI, 1.08 to 1.45]; OC use of five or more years: HR, 1.17 [95 percent CI, 1.0 to 1.37]). There was a decrease in TKA risk for each one-year increase in menstruation (HR, 0.99; 95 percent CI, 0.97 to 0.99). However, with adjustments, these associations remained significant only for women of normal weight at early reproductive age.
Source: Medical Xpress